In obstructive snooze apnea (OSA), doses around 250 mg/working day are actually perfectly-tolerated but there is no consistent evidence of additional benefit outside of the 150 mg/day.

danazol will increase the degree or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

Avoid coadministration of delicate CYP3A4 substrates with ivosidenib or substitute with substitute therapies. If coadministration is unavoidable, observe people for lack of therapeutic influence of such medicine.

Every capsule-shaped, white to off white, scored pill is debossed with “PROVIGIL” on one facet and “two hundred MG” on the opposite.

Lots of individuals use this dose for very long periods as a caffeine substitution to help them wake up each morning. It encourages a gentle, reduced-quality sensation of wakefulness about 30-forty five minutes soon after use.

Employing this drugs with any of the following medicines just isn't advised. Your medical doctor may well decide not to deal with you with this medication or alter some of the other medicines you are taking.

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Reassess degree of sleepiness often; if employed adjunctively with constant constructive airway force (CPAP): Periodic evaluation of CPAP compliance is important

Keep an eye on Closely (one)crofelemer increases amounts of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Crofelemer has the possible to inhibit CYP3A4 at concentrations anticipated in the gut; not likely to inhibit systemically since minimally absorbed.

stiripentol will raise the level or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Closely. Consider lessening the dose of CYP2C19 substrates, if adverse reactions are seasoned when administered concomitantly with stiripentol.

Each individual capsule-shaped, white to off white tablet is debossed with “PROVIGIL” on a single aspect and “one hundred MG” on the opposite.

It is crucial to inform your medical doctor when you grow to be pregnant. Your medical professional might want you to affix a pregnancy registry for sufferers getting this medicine.

Contraindicated (two)modafinil will improve the stage or influence of mavacamten by impacting hepatic enzyme CYP2C19 metabolism. Contraindicated. Sturdy or reasonable CYP2C19 inhibitors may possibly enhance mavacamten systemic exposure, leading to heart failure because of systolic dysfunction.

Even though modafinil is normally found for being Safe and sound and significant adverse effects are uncommon, which include in pediatric narcolepsy conditions (sleep Problems in young children), There may be proof that long-term usage can result in tolerance in a few men and read more women.